CDKN2A and neoplasm: Multivariate analysis revealed that p16-expression (hazard ratio [HR] = 2.11, 95 % confidence interval [CI] = 1.13–3.95, p = 0.001), nodal status (HR = 2.74, 95 % CI = 1.50–5.02, p = 0.019), and tumor grade (HR = 2.80, 95 % CI = 1.33–5.90, p = 0.007) were independent prognostic factors for OS (Table 3).