TNF and obesity due to melanocortin 4 receptor deficiency: Specifically, some of the most known candidate genes and genetic loci for asthma and allergy [6, 11] have already been linked [12] to the pathogenesis of obesity such as the tumor necrosis factor alpha (TNF-a) gene [12], the protein kinase C alpha (PRKCA) gene [13] and β2‐adrenergic receptor (ADRB2) [14].