MH induction-effects by the current systemic drugs are not always satisfied, for example, anti-tumor necrosis factor (TNF) agents alone can achieve only 30.1% MH in Crohn’s disease (CD) and approximately 60% MH at week 8 in ulcerative colitis (UC), in spite of their primary usage [5–7]. The gene discussed is TNF; the disease is Crohn disease.