In fact, we reported that resistance to paclitaxel-induced apoptosis in MDA-MB-231breast cancer cells is related to the inability to disrupt the interaction between BCL-xL, an anti-apoptotic BCL-2 family protein, and BAK; and BCL-xL accumulation may be of prognostic value in paclitaxel-treated patients [18]. The gene discussed is BCL2L1; the disease is cancer.