LATS1 and colonic neoplasm: However, the effects elicited by the activation of HIPPO pathway under ER stress may not depend on LATS1/2 inasmuch as other kinases downstream of MST1 and 2 such as the nuclear dbf2-related (NDR) kinase have been implicated in YAP phosphorylation and inhibition of liver and colon cancer [40, 41].