LATS1 KO mice develop fibrosarcomas by 4-10 months of age whereas disruption of other key components of the HIPPO pathway has led to the development of many tumor forms in mice including hepatocellular carcinoma, Schwannoma, squamous cell carcinoma or malignant mesothelioma [47, 48]. This evidence concerns the gene LATS1 and malignant mesothelioma.