A comparable phosphorylation pattern, but modified CREB forms as demonstrated by two bands at ~90 and ~120 kDa were observed in the HER-2/neu+ breast cancer cell line SKBR3 under hypoxic treatment (Supplementary Figure 1C), while the 60 kDa band was neither visible with CREB nor with pCREB antibodies. This evidence concerns the gene CREB1 and breast cancer.