This could be influenced by the modulation of signalling cascades upstream of CREB as well as the induction of the CRE-dependent gene expression downstream of CREB, e.g. matrix metalloproteinases (MMPs), adhesion molecules and different survival factors [20, 27] leading to an increased tumor growth, prevention of cell death, enhanced metastasis formation and angiogenesis [28]. This evidence concerns the gene CREB1 and neoplasm.