The pathogenic mechanism involving both LTBP2 and PXDN together in glaucoma is not clearly established, however it has been proposed that both of them are linked to each other via COL4A2 http://pathwaynet.princeton.edu/predictions/geneset/?network=human-functional-relation&geneset=4314%2C14540#. The gene discussed is LTBP2; the disease is glaucoma.