In conclusion, we have defined that lncRNA BC087858 over-expression was significantly associated with poor prognosis of NSCLC patients with acquired resistance to EGFR-TKIs and the correlation of over-expression of lncRNA BC087858 on PFS for patients with acquired resistance to EGFR-TKIs was from non-T790M subgroup. Here, EGFR is linked to non-small cell lung carcinoma.