In conclusion, we have identified the increased expression of CCL2/CCR2 in non-metastatic ccRCC as an independent unfavorable prognostic factor, which could be integrated with pathologic T stage, Fuhrman grade and the size of the tumor to generate a nomogram to give a better risk stratification for patients with different prognosis. The gene discussed is CCL2; the disease is nonpapillary renal cell carcinoma.