Analysis of commonly upregulated genes by wt-p53 in breast cancer patients from Troester et al. [32] and loss of CTBP1 in MCF-7 cells from Di et al. [35] also identified only p21 and BTG2 (data not shown) which further supported that miR-644a mediated upregulation of wt-p53 and p21 is via CTBP1 downregulation. This evidence concerns the gene CDKN1A and breast cancer.