Moreover, given the heterozygous status of the LMNA rs4641 allele in the HGPS patient, carrying the rs4641 “C” genotype in cis of the c.1824C > T mutation, we showed that the use of morpholino-Ex10 “C allele” was about 25% more effective in reducing Progerin levels than the Ex10-morpholino “T allele”. The gene discussed is LMNA; the disease is Hutchinson-Gilford progeria syndrome.