Taken together, although the precise mechanism by which PPARγ regulates renal water reabsorption remains only partially understood, increasing evidence suggests that increased expression of the AQP2 gene and enhanced membrane targeting of the AQP2 protein play an important role in mediating PPARγ agonist-induced fluid retention, especially in T2DM. The gene discussed is PPARG; the disease is type 2 diabetes mellitus.