MLH1 and cancer: It reverses hypermethylation of several known tumor suppressor genes such as p16, retinoic acid receptor (RAR), O6-methylguanine DNA methyltransferase (MGMT), and MutL homolog 1 (MLH1) in a concentration- and time-dependent manner; it is the most promising and potent modulator of histone markers in cancer cells; and it modifies the expressions of 61 miRNAs [86].