IGF1 and neoplasm: Anti-angiogenic action of apigenin is similar to that of EGCG, as well as inhibition of tumor growth, suppression of progression and invasion of tumor and prevention of metastasis through altering Bcl-2 associated X protein (Bax)/Bcl-2 ratio, MAPK and PI3/Akt signaling and through modulation of insulin-like growth factor (IGF), VEGF, MMP’s and transforming growth factor TGF-β1 [13,93].