As previously described for WD/DDLPS [4, 6, 24], the three metastases had a common and very similar core set of amplified segments on chromosome 12, including MDM2, HMGA2, and CDK4. Interestingly, we did not see loss of 11q23-24, which has been associated with greater genomic complexity [26]. This evidence concerns the gene CDK4 and Wilson disease.