Furthermore, over-expression of MYC significantly repressed the activity of PPR-3 which contains both canonical E-box 2 and non-canonical E-box 3 in HepG2 and L02 cells, however, it could not change the activity of PPR-3 in GBM U87 and U251 cells (Figure 4C). The gene discussed is MYC; the disease is glioblastoma.