To further characterize the mode of activation of divalent TRAILmim/DR5, we compared the activity of one member in this series (referred here to as 2d, see supporting information for corresponding formula) on the B cell lymphoma BJAB, the T cell lymphoma Jurkat and the epithelial colorectal carcinoma HCT116 that show comparable DR5 surface expression (Figure 1A and 1B) in comparison with the activity of the human recombinant (rh) hexameric form of TRAIL (SuperKiller TRAIL, referred to as SPK). Here, TNFSF10 is linked to T-cell non-Hodgkin lymphoma.