Importantly, downregulation of WISP1 in vivo also induced decrease in expression of ICAM-1, VCAM-1, VEGFC, MMP-2, MMP-9 and increase in E-cadherin, suggesting that WISP1 downregulation not only inhibited tumor growth but also suppressed tumor metastasis in vivo. The gene discussed is CCN4; the disease is neoplasm.