Importantly, analysis of expression of these three genes in tumor samples from 35 patients confirms these findings, since the expression of N-cadherin was significantly increased in patients with stage III-IV in comparison with patients with stage I-II, and correlates, in a highly significant manner, with the expression of GPBAR1 in the tumors (Figure 4D), further confirming the fact that expression of GPBAR1 correlates with advanced disease and poor prognosis [20, 25]. This evidence concerns the gene GPBAR1 and neoplasm.