K-ras, mitogen-activated protein (MAP)-ERK kinase (MEK), and Extracellular signal-regulated kinase (ERK) signaling are downstream signaling of EGFR [15–18], and we recently reported crosstalk between Hippo/YAP and EGFR/ERK signaling pathways in human NSCLC cells [19]. Here, EGFR is linked to non-small cell lung carcinoma.