Vitamin D is also a neuroactive steroid hormone with multiple functions in the nervous system, mediated by VDR, where they are widespread in the brain, implying that they may take part in the regulation of brain functions.17,18 In a mouse model with induced chemical seizures, Kalueff’s team directly linked the genetic ablation of VDR to increase seizure susceptibility and revealed that vitamin D has anti-convulsive activity in an epilepsy animal model.17 The findings in Kalueff’s study are consistent with the observations in patients with hypo-vitamin D and rickets, as well as our patient. This evidence concerns the gene VDR and epilepsy.