(1) Epilepsy may be affected by VDR genetic ablation by disrupting VDR-mediated modulation of certain brain genes that may alter the baseline levels of endogenous proconvulsants and anticonvulsants, leading to the increase in epilepsy susceptibility.18 (2) Vitamin D has a role in stimulating the expression of Ca-binding proteins, which are also known to exert anti-epileptic effects. The gene discussed is VDR; the disease is epilepsy.