Mice actively immunised with MuSK generated a response characterised by IgG1 (which has characteristics similar to human IgG4), IL-4, and IL-10, analogous to the MuSK immunology found in MuSK MG patients32,35,69, suggesting that there is something about the antigen itself that determines the immunological characteristics. The gene discussed is IL10; the disease is myasthenia gravis.