Mutations inGJA1 cause erythrokeratodermia variabilis et progressiva. In 2015, Boydenet al. reported that autosomal dominant mutations inGJA1 cause erythrokeratodermia variabilis et progressiva (EKVP)38, a rare genetic disorder characterized by transient figurate erythematous patches on a background of generalized scaling.GJA1 encodes connexin 43 (Cx43), which is present throughout the epidermis and is expressed in every tissue type39. The gene discussed is GJA1; the disease is hereditary disease.