CSF2 and melanoma: In an exploratory analysis of OPTiM, patients with stages IIIB/IIIC/IVM1a melanoma benefited the most from talimogene laherparepvec, with DRR as high as 33% for stages IIIB/IIIC and 16% for stage IVM1a, and median OS that was 41.1 months for patients with stage IIIB/IIIC/IVM1a disease in the talimogene laherparepvec arm compared to 21.5 months in the GM‐CSF arm (HR = 0.57; 95% CI = 0.40–0.80; p < .001 descriptive).16