Its ability to bioactivate xenobiotics into toxic/reactive intermediates and its high propensity for generating reactive O2 species (ROS) have implicated CYP2E1 in the pathogenesis of toxic liver damage, alcoholic liver disease, nonalcoholic steatohepatitis (NASH), diabetes, and obesity7, 8, 9, 10, 11. The gene discussed is CYP2E1; the disease is metabolic dysfunction-associated steatohepatitis.