In this, FOXO/FKHR transcription factors, critical nodes at the intersection of the JNK- and AMPK-signaling networks18, 19, 20, 21, 22, 23, play a key regulatory role to insure that the hepatoprotective adiponectin-AMPK-FOXO-signaling largely prevails over the liver injury-promoting JNK1-pathway, thereby counteracting/delaying any pathogenic progression into NASH in CHIP−/−-livers. Here, PRKAA2 is linked to metabolic dysfunction-associated steatohepatitis.