Consequently, ATP-consuming biosynthetic processes would be turned off, ATP-generating catabolic processes turned on35, and antioxidant responses ushered that directly counteract and thus attenuate the concurrent pro-NAFLD/NASH scenario induced by hepatic CYP2E1-ROS-JNK1-activation. The gene discussed is MAPK8; the disease is metabolic dysfunction-associated steatotic liver disease.