In this, FOXO/FKHR transcription factors, critical nodes at the intersection of the JNK- and AMPK-signaling networks18, 19, 20, 21, 22, 23, play a key regulatory role to insure that the hepatoprotective adiponectin-AMPK-FOXO-signaling largely prevails over the liver injury-promoting JNK1-pathway, thereby counteracting/delaying any pathogenic progression into NASH in CHIP−/−-livers. The gene discussed is STUB1; the disease is metabolic dysfunction-associated steatohepatitis.