We also observed a significant difference between the APP/PS1 and Pdx1+/−/APP/PS1 mice in the PS1 levels, the total amount of CTF, and the APP proteolytic processing that is involved in Aβ production; these findings confirm the direct involvement of this proteolytic pathway in the observed biological effects of hyperglycemia that were also found in this mouse model. This evidence concerns the gene PDX1 and Hyperglycemia.