One of these snoRNAs, SNORD115, regulates the processing of the 5HT2C pre‐mRNA (Kishore & Stamm, 2006; Kishore et al, 2010; Shen et al, 2011), showing functions of C/D box snoRNAs different from the 2′‐O‐RNA methylation normally attributed to these non‐coding RNAs (Falaleeva et al, 2016), and suggesting that a dysregulation of 5HT2C function contributes to the hyperphagia observed in PWS. This evidence concerns the gene HTR2C and Prader-Willi syndrome.