CT26 cells are relatively insensitive to IFN‐γ‐induced type I immunity and cytotoxicity since IFN‐γ downregulates a CD8+ cell epitope favoring tumor escape (Beatty & Paterson, 2000); therefore, the anti‐tumor effect mediated by NK cells is presumably not due to the activation of adaptive immunity. Here, IFNG is linked to neoplasm.