Recent conference reports described increased weight gain on high fat diet (HFD)-fed mouse with through-life expression of GLO-1 siRNA and Glo-1 deficiency, compared to wild-type controls [76], and decreased weight gain in Glo-1 overexpressing transgenic mice [77], suggesting a functional role of Glo-1 and dicarbonyl stress in obesity. This evidence concerns the gene GLO1 and obesity due to melanocortin 4 receptor deficiency.