This is consistent with CD43/45-mediated adherence of Actinomyces naeslundii, expressing Galβ-1,3-Gal(NAc)-specific adhesins, to polymorphonuclear leukocytes or promyelocytic leukemia cells (70) and the involvement of CD45 in the induction of cytokine production, as for the T-antigen-specific jacalin (plant lectin) that recognizes CD45 on T lymphocytes and induces cytokine secretion (71). This evidence concerns the gene SPN and acute promyelocytic leukemia.