NPC1 and viral infectious disease: In addition, LSD1, HSPA5, and CAV-1 have been reported to influence the efficiency of viral infection and replication27, 28, 29, 30, 31; NPC1 is the key influencer for Ebola virus to enter cells32; SEC22b can inhibit the release of infectious viral progeny33; and the down-regulation of CD59 is associated with the development of hepatitis B cytotoxicity34.