CDKN2A and neoplasm: Advantages of the program in CDKN2A/p16-Leiden mutation carriers are that more tumours are identified at a resectable stage (75 % vs. 15–20 % in symptomatic patients) and that the prognosis of patients with screen-detected tumours is better (5-year survival is 24 %) than that of symptomatic patients (5–7 %) [14].