In this work, given the relevance of soluble monomeric as well as oligomeric state of Aβ1‐42 in AD pathogenesis, we studied their role in altering the aggregation and conformation of Tau protein when injected in mice with a pure human Tau (hTau) background (Andorfer et al., 2003). The gene discussed is MAPT; the disease is Alzheimer disease.