Other cytokines besides IL-1β (tumor necrosis factor (TNF)-α, IL-6, IL-8, prostaglandin E2 (PGE2), and nitric oxide (NO) [26, 27]) may also be involved in the complicated pathogenesis of disc degeneration, including upregulation of MMP genes. This evidence concerns the gene IL6 and intervertebral disk degenerative disorder.