In conclusion, a total of 393 DEGs were identified between osteocytes co-cultured with and without myeloma cells, and KLF4, IRF8, EGF, EGR1, S1PR1, C3AR1, and NPY1R might be involved in osteocyte cell apoptosis induced by MM cells. The gene discussed is S1PR1; the disease is Miyoshi myopathy.