FOXO1 and myeloid sarcoma: It was reported that PI3K signalling acts to downregulate TLR signalling through the induction of IL-10 via mammalian target of rapamycin (mTOR), the activation of GSK-3β, and the phosphorylation of Foxo138, 39, 40, so mTOR and Foxo1 may also act as upstream mediators of p-GSK-3β-induced IL-10 production in MS-treated macrophages.