ZOL thereby blocks one of the dysfunctional Hippo pathways and combinatory effects of ZOL and Ad-delE1B55 can inhibit a possible cross-talk between NF/Merlin and the p53 pathways in mesothelioma with deletion of both INK4A/ARF and NF/Merlin regions. The gene discussed is NFASC; the disease is mesothelioma.