ZOL increased an expression level of p53 in MSTO-211H cells, which was induced by Ad-delE1B55 at 48 h after the infection, and subsequently activated apoptotic signal pathways which was evidenced by up-regulated cleavages of caspase-8, −9 and −3, and PARP even without Bid truncation. The gene discussed is CASP8; the disease is infection.