Although the influence of non-statin lipid-modifying drugs on the linear relationships between these lipid/lipoprotein parameters has been less well studied, a recent analysis evaluated the effects of ERN/LRPT, simvastatin (SIMVA), and ERN/LRPT + SIMVA on apoB:LDL-C and apoB:non–HDL-C correlations in patients with dyslipidemia [35]. This evidence concerns the gene APOB and metabolic syndrome.