Similar to inhibition of Rac1, inhibition of PAK1 was followed by a significant increase of soluble G-actin over F-actin in human endometrial cancer Ishikawa cells (Fig. 5b; **P = 0.008, Fig. 5d; *P = 0.034), an effect thus mimicking the effect of LeftyA treatment (Fig. 5b; ***P = 0.0007, Fig. 5d; *P = 0.045). The gene discussed is RAC1; the disease is endometrial cancer.