CREB1 and Anxiety: To determine the role of hippocampal CREB activity in the modulation of anxiety-related behaviors by 5-HT1aR, we generated recombinant lentivirus LV-CREB133-GFP expressing a dominant negative CREB which could not be phosphorylated at Ser133 to specifically reduce CREB activity, and LV-VP16-CREB-GFP expressing a constitutively active fusion protein VP16-CREB which could be phosphorylated by itself to specifically increase CREB activity21.