CREB1 and viral infectious disease: To test whether the regulation of anxiety by 5-HT1aR dependents on CREB activation, we treated the LV-CREB133-GFP-infected mice at d 7 after virus infection with 8-OH-DPAT (i.p., 0.1 mg/kg/d × 21 d), a selective 5-HT1aR agonist, and performed the NSF and EPM tests at 24 h after the last 8-OH-DPAT injection.