Similarly, we infused LV-VP16-CREB-GFP or LV-GFP into the hippocampus of mice by microinjection, and 7 days later, delivered NAN-190 (10−5 M, 2 μl) into the hippocampus, and measured dendritic branching and the number of dendritic spines by Golgi staining 14 d after virus infection. Here, CREB1 is linked to viral infectious disease.