From the present results, it could be hypothesized that the HDAC inhibitor-induced histone acetylation was, at least to some extent, simultaneously associated with both function of the ECB system (CB1 receptors), one of the targets for HDAC inhibitors, and stressor (NC- and/or IM)-induced emotion-related (anxiety- and depression-like) behaviors. Here, HDAC9 is linked to depressive disorder.