CNR1 and Anxiety: Against these anxiety-like behavioral alterations, statistically significant antagonistic effects, i.e. recoveries from both attenuated percentage of entries into open arms and attenuated percentage of time spent on open arms, were observed in both NC, IM and NC-IM groups co-treated with the HDAC inhibitor SB (50–200 mg/kg), VA (200–400 mg/kg) or the CB1 agonist AC (0.2–1 mg/kg) (Fig 1A–1C).