Furthermore, the activation of the ECB system was involved in the attenuation of the stress-related neuromolecular responses accompanying anxiety- and depression-like behaviors (e.g. responses of the neuroendocrine system, c-fos expression and decreased hippocampal neurogenesis), which seemed to be associated with epigenetic histone acetylation [51, 132–135]. This evidence concerns the gene FOS and depressive disorder.