The aberrant over expression of the four miRNAs and consistent down regulation of two miRs showed a good correlation not only with tumor grade, clinical stage, lymph node status and hormone receptor expression but also with majority of clinicoepidemiological and demographic risk factors often associated with the development of breast cancer (see S1 Table and Table 2a and 2b). This evidence concerns the gene NR4A1 and breast carcinoma.