The results revealed a significant correlation between increased expression of these four serum miRs (fold change 17.29; 10.60; 17.08 and 14.85 respectively) and younger age (<35 year) (69.56%), pre-menopausal status (73.91%), early age of menarche (<13 year), higher mitotic activity and increased Ki67 expression, increasing tumor grade and clinical stage and lymph node negativity of TNBC patients (S1 Table). The gene discussed is MKI67; the disease is neoplasm.