Several lines of evidence involved somatostatin (Sst) in mood disorders,45 and we previously observed that Sst was downregulated in the brain of Crtc1−/− mice.13 Therefore, we investigated whether Agmat might be expressed in somatostatinergic interneurons by performing double immunostaining of Agmat- and Sst-expressing cells. The gene discussed is CRTC1; the disease is mood disorder.