IFNA1 and hepatitis C virus infection: Recently, the presence of F/ARFP antibody was associated with decreased CpG-induced IFNα production by peripheral blood mononuclear cells (PBMC) in hepatitis C patients; the addition of F/ARFP protein reduced IFNα secretion by PBMC, suggesting potential parallel suppression of another PRR signaling by F/ARFP [42].