Many studies have shown that the expression of TGFβ2 in the aqueous humor of POAG patients is elevated by approximately 50% to 100% compared to control individuals.31 The same studies also showed that there is a wide range of TGFβ2 expression in nonglaucomatous individuals, which may explain the variation in histone acetylation seen in our ChIP data (Table 2). Here, TGFB2 is linked to open-angle glaucoma.