Several HAT inhibitors, such as anacardic acid and curcumin, have been shown to inhibit Jurkat T-cell leukemia cells and prevent heart failure in rats, respectively.49,50 Kanthasamy et al.51 showed that anacardic acid attenuated dieldrin-induced damage in primary mesencephalic cells.51 Like HDAC inhibitors, HAT inhibitors may affect genes that are selectively activated in POAG. Here, TMPRSS11D is linked to open-angle glaucoma.