Previous studies showed that elevated TGFβ2 in the TM causes ocular hypertension (OHT) in perfusion-cultured human anterior segments and in mouse eyes.13, , –16 Since TDP-A increased the expression of TGFβ2 in TM cells, we studied whether TDP-A is able to elevate IOP as well as alter ECM and cytoskeletal proteins. The gene discussed is DNM2; the disease is ocular hypertension.