TGFB2 and open-angle glaucoma: Many studies have shown that the expression of TGFβ2 is significantly higher in the glaucomatous AH as well as GTM tissues.4, –6 Activation of the TGFβ pathway by elevated TGFβ2 leads to increased production of ECM, cytoskeletal changes, and altered cell adhesion in the TM.7, , –10 All these TGFβ2-induced changes in the TM also are found in the GTM,8,11,12 suggesting that TGFβ2 not only is POAG-associated, but also a causative factor of this disease.