KLRD1 and human African trypanosomiasis: Further investigation is needed to identify the NK cell receptor(s) and B cell associated ligand(s) that mediate trypanosome infection-induced B cell killing, to determine how NK cell-mediated cytotoxicity interacts with other processes that contribute to trypanosomiasis-induced pathology [83–87], and importantly, to determine the contribution, if any, of NK cells to trypanosomiasis-pathology in host species other than mice, and in pathology associated with diseases in addition to African trypanosomiasis.