LAMP1 and infection: In this regard adoptive transfer studies of efluor 670-labelled splenic NKp46+NK cells into naïve and T. brucei infected recipients indicated they were the precursors of the putative “spent NK cells” elicited by T. brucei infection, and further studies showed that NKp46+CD107a- NK cells are sustained in the spleen throughout infection and hence may be responsible for on-going deletion of newly arising B2 B cells.