ASIC2 and adenoid cystic carcinoma: Furthermore, although ASIC2a and ASIC3 are highly expressed in adenoid cystic carcinoma [58], surface expression of ASIC2 abolished the amiloride-sensitive inward Na+ current and promoted a reversion of a high-grade glioma cell to a more normal (i.e., nonmalignant) astrocytic phenotype [39].