However, Liu et al. reported that knockdown of ASIC2a could increase the acidosis-induced cytotoxicity via the intracellular calcium overload in C6 glioma cells, revealing that ASIC2a could change the properties of ASICs, such as acid sensitivity and Ca2+ permeability, and subsequently affect the invasion and migration of the cells. The gene discussed is ASIC2; the disease is central nervous system cancer.