Similar studies further reported that interaction between Hsc70 and ASIC2 can increase retention of ASIC2 in the endoplasmic reticulum in cells but that silencing Hsc70 may abolish the interaction, increase the surface expression of ASIC2 on cells, and inhibit cell migration, thereby also promoting reversion of a high-grade glioma cell to a more normal astrocytic phenotype [57, 59]. Here, ASIC2 is linked to central nervous system cancer.