It is known that, after antigen challenges to the atopic dermatitis tissues or sensitized individuals, expressions of adhesion molecules in the vascular endothelial cells such as E-selectin and ICAM-1 are increased and it was reported that the movement and migration of inflammatory cells are promoted by the increase of these cell adhesion molecules in the vascular endothelial cells [19, 20]. The gene discussed is SELE; the disease is atopic eczema.