IL4 and allergic disease: Taken together, SHHTE suppressed IgE production from B-lymphocytes not only by promoting expression of Treg cytokines such as IL-10 and TGF-β, which in turn suppressed Th2 cytokines (IL-4, IL-5) playing a critical role in the pathological mechanisms of allergies, but also by suppressing expressions of cytokines IFN-γ and IL-17A of Th1 and Th17 helper T cells, which worsens allergic reactions and prevents activation of T lymphocytes induced by allergens.