ACE and hydrops fetalis: Despite advanced medical care for patients with HF, the average 5-year survival is about 50%.3 Currently, various types of therapeutic agents are used for HF as the standard treatment - including diuretics, angiotensin-receptor blockers (ARB), angiotensin-converting enzymes inhibitors (ACE-I), and beta-blockers.4 These drugs still play an important role in the treatment of HF patients.