Furthermore, HmuY seems to participate in a delayed host response through the increase of IL-10 and IL-6 levels and IgG and IgG1 levels of anti-HmuY antibodies and decrease of IL-8 levels in individuals with chronic periodontitis [104, 105]. P. gingivalis HmuY also evokes inflammatory responses in peripheral blood mononuclear cells (PBMC) derived from chronic periodontitis individuals, eliciting CCL2 and IL-18 as well as inhibiting NFKBIL-1 and IL-10 [105]. This evidence concerns the gene IL18 and periodontitis.