In contrast, CCL2/CCR2-knockout MRL/lpr mice exhibited reduced circulating anti-dsDNA IgG, diminished lymphadenopathy, and decreased percentage of circulating CD8+ T cells, suggesting CCL2/CCR2 network also contributes to systemic autoimmune reactions in the immune tissues, through which LN progression was indirectly promoted [55, 57]. This evidence concerns the gene CCL2 and Lymphadenopathy.